{"id":467,"date":"2024-07-06T17:00:47","date_gmt":"2024-07-06T17:00:47","guid":{"rendered":"https:\/\/coloradesign.com\/cardio\/?post_type=research-study&#038;p=467"},"modified":"2024-07-06T17:00:49","modified_gmt":"2024-07-06T17:00:49","slug":"shasta-3","status":"publish","type":"research-study","link":"https:\/\/coloradesign.com\/cardio\/research-study\/shasta-3\/","title":{"rendered":"SHASTA 3"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with severe hypertriglyceridemia (SHTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo, and be evaluated for efficacy and safety. After month 12, eligible participants will be offered an opportunity to continue in an optional open-label extension under a separate protocol.<\/p>\n\n\n<p>[button title=&#8221;Read Study&#8221; link=&#8221;https:\/\/clinicaltrials.gov\/study\/NCT06347003&#8243; target=&#8221;_blank&#8221; align=&#8221;&#8221; icon=&#8221;&#8221; icon_position=&#8221;&#8221; color=&#8221;&#8221; font_color=&#8221;&#8221; size=&#8221;2&#8243; full_width=&#8221;&#8221; class=&#8221;&#8221; download=&#8221;&#8221; rel=&#8221;&#8221;]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with severe hypertriglyceridemia (SHTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo, and be evaluated for efficacy and safety. After month 12, eligible participants will &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/coloradesign.com\/cardio\/research-study\/shasta-3\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;SHASTA 3&#8221;<\/span><\/a><\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"study-category":[],"class_list":["post-467","research-study","type-research-study","status-publish","format-standard","hentry","entry"],"acf":[],"_links":{"self":[{"href":"https:\/\/coloradesign.com\/cardio\/wp-json\/wp\/v2\/research-study\/467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/coloradesign.com\/cardio\/wp-json\/wp\/v2\/research-study"}],"about":[{"href":"https:\/\/coloradesign.com\/cardio\/wp-json\/wp\/v2\/types\/research-study"}],"version-history":[{"count":1,"href":"https:\/\/coloradesign.com\/cardio\/wp-json\/wp\/v2\/research-study\/467\/revisions"}],"predecessor-version":[{"id":468,"href":"https:\/\/coloradesign.com\/cardio\/wp-json\/wp\/v2\/research-study\/467\/revisions\/468"}],"wp:attachment":[{"href":"https:\/\/coloradesign.com\/cardio\/wp-json\/wp\/v2\/media?parent=467"}],"wp:term":[{"taxonomy":"study-category","embeddable":true,"href":"https:\/\/coloradesign.com\/cardio\/wp-json\/wp\/v2\/study-category?post=467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}